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The use of innovative strategies such as multi-omics (transcriptomics, epigenetics, proteomics, and metabolomics) and innovative in silico network biology evaluation is another objective of our COST Action in order to identify new therapeutic targets for cardioprotection. The pathophysiology of the ischemic heart is very complex; therefore, large-scale, unbiased, global approaches capable of identifying multiple branches of the signaling networks activated in the ischemic/reperfused heart might be a preferred approach in the discovery of novel targets. Proteomics and metabolomics offer simultaneous readouts of hundreds of proteins and metabolites altered in the ischemic myocardium, and the possibility of integrating different -omics approaches gives new hope for a better understanding of the complicated molecular signaling activated by acute myocardial ischemia and reperfusion ( Perrino et al., 2017 ; Varga et al., 2015 ). In general, WG1 will contribute to an improved knowledge of the sequence of molecular events triggered by ischemia-reperfusion that ultimately lead to tissue damage. This is required for the development of novel and effective therapeutic approaches. The identification of novel therapeutic targets may lead to the design, synthesis, and testing of novel chemical modulators in both cells and animals.

Expected Research Outputs of WG1

1. To identify at least 6 novel targets for cardioprotection either within the cardiomyocyte (newly discovered signaling pathways) or outside the cardiomyocyte (involving inflammatory cells, fibroblasts, the microvasculature, red blood cells, or platelets).

2. To identify at least 3 innovative strategies for identifying novel targets for cardioprotection such as epigenetics or multi-omics strategies (genomics, transcriptomics, metabolomics, lipidomics or proteomics).

Working Group 2: Combination Therapy

The majority of experimental studies have used a single-targeted approach, directed to a single signaling pathway and target within the cardiomyocyte. However, there exists a number of different cardioprotective pathways underlie ischemic conditioning. Furthermore, the detrimental effects of acute IRI on the heart are complex, interdependent, and involve a number of players outside of the cardiomyocyte such as the microvasculature, extracellular matrix, inflammatory cells, red blood cells and platelets. For example, it has been shown that multiple cardioprotective interventions (each with a different mechanism of action), – e.g., mild hypothermia, sodium/hydrogen exchange blocker plus a P2Y12 inhibitor, – reduced MI size to a greater extent beyond the one that achieved by a P2Y12 inhibitor alone ( Yang et al., 2013b ; Yang et al., 2012 ; Yang et al., 2013a ; Yang et al., 2013c ). Here we will utilize the joint expertise of different European network members to investigate combination therapy directed to multiple cardioprotective pathways and targets both within and outside the cardiomyocyte as an innovative treatment strategy for cardioprotection.

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What Does the Supreme Court Look Like Without Kennedy?
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President Donald Trump said he has a list of about 25 contenders to replace retiring Supreme Court Justice Anthony Kennedy.

Here they are:

Brett Kavanaugh: Judge on the U.S. Court of Appeals for the D.C. Circuit and former law clerk to Kennedy.

Brett Kavanaugh

Photographer: Chris Maddaloni/CQ-Roll Call Group

Amy Coney Barrett: Judge on the Chicago-based 7th U.S. Circuit Court of Appeals. The former law professor at the University of Notre Dame has been questioned by Democrats over the role her Catholic faith would play on the bench.

Kevin Newsom: Judge on the Atlanta-based 11th U.S. Circuit Court of Appeals. The former solicitor general of Alabama was previously a clerk for Justice David Souter, a liberal who retired from the Supreme Court in 2009.

Britt Grant: Justice on the Georgia Supreme Court. The former solicitor general of Georgia previously clerked for Kavanaugh on the D.C. Circuit.

William Pryor: Judge on the 11th U.S. Circuit Court of Appeals, whose nomination by President George W. Bush to a federal appeals court sparked a two-year partisan battle before his confirmation in 2005.

William Pryor

Photographer: Cliff Owen/AP Photo

Don Willett: Judge on the New Orleans-based 5th U.S. Circuit Court of Appeals, perhaps best known for his colorful postings on Twitter, including one that said, "Who would the Donald Name to #SCOTUS? The mind reels. *weeps—can’t finish tweet*"

Allison Eid: Judge on the Denver-based 10th U.S. Circuit Court of Appeals. The former justice on the Colorado Supreme Court was nominated last year by Trump to fill the seat vacated by U.S. Supreme Court Justice Neil Gorsuch.

Allison Eid

Photographer: Tom Williams/CQ-Roll Call Group

Patrick Wyrick: Justice on the Oklahoma Supreme Court.

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By Julia Pimentel

News + Pop Culture | @julia_rdsp

Donald Trump’s presidency, what with its xenophobic, alarmist rhetoric informed by deep-rooted ignorance and fear, could also be described as a rather successful experiment in a live-action segment on Fox News . As if having the president parrot the opinions of the network of choice of racists everywhere wasn’t enough, we will now have someone from the inside on the government’s payroll: Trump will replace Steve Goldstein, a top aide to former Secretary of State Rex Tillerson, who was also fired yesterday, with Harriet Nauert Norby, a State Department spokeswoman and former Fox and Friends co-host. (Since she’s a woman, Trump has also now furthered feminism as a bonus gift. Cool!)

Trump moving fast at State: Spokeswoman Heather Nauert named acting undersecretary for public diplomacy, replacing Steve Goldstein

NEW from the WH: "The following individual to be Acting Under Secretary of State for Public Diplomacy: Heather Nauert Norby of New York." She replaces Steve Goldstein, who was fired today for breaking from the official line on when Rex Tillerson found out he'd been axed.

One way to understand the significance of this change is to explain the bizarre way Tillerson was fired, and to try to pin down when he realized he was being booted. When Tillerson provided a statement confirming that he would be leaving his position as Secretary of State, he said that he had only learned of his firing hours before on Twitter that same day. The White House, however, claims that Tillerson had been told on Friday, thereby undermining him and making him seem stupid.

Goldstein, the undersecretary of state for public diplomacy and one of Tillerson’s top aides, released a statement on Tuesday that suggested this wasn’t true. The has two unnamed senior department officials that support Goldstein and Tillerson’s version of events by saying that Tillerson “received a call from John Kelly, Trump’s chief of staff, on Friday, but was only told that there might be a presidential tweet that would concern him. Kelly didn’t tell Tillerson what the tweet might say or when it might actually publish.”

In other words, Goldstein was fired along with Tillerson for supporting his former boss in suggesting that Trump had mismanaged his own staff and couldn’t even fire people properly, which is literally the only thing the Apprentice host is qualified to do. Keeping with the theme, it is generally believed one of the reasons Tillerson was fired is because he sided with the United Kingdom and openly blamed Russia for the recent poisonings of former Russian spies in Salisbury.

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After two weeks, during which he avoided contacting Vicky at her request, Tim got an email from the university saying they were launching an investigation. At the first meeting, he learned that all possible punishments, including expulsion, were on the table. "Apparently," he says, "two students acting outside a university function, off university property, are still under their jurisdiction."

That's less scary than a visit from the cops but can actually turn out worse. You see, while the police can send you to jail, they also have a much higher burden of proof ... and you actually get a lawyer to defend you . If you're accused of a crime in college, don't count on getting to appeal or refute evidence. Faculty from law schools are now even criticizing their own universities' policies as unfair to the accused, and some students are starting to hire attorneys and SARGOSSA Ankle boots free shipping 2014 new 2NcTgeHG9
for violating their due process rights.

Comstock/Stockbyte/Getty Images So if this seems like a far worse idea than letting established legal institutions handle things, that's because it is .

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And rights have to extend to both the accuser and the accused. Even if there is no vast false-rape epidemic sweeping the nation, some accusations are false, as Rolling Stone and others uncovered with Mr. Bean-esque clumsiness. Some students have even had to produce video footage to prove their innocence or were expelled even though juries found no evidence against them . It's tempting to assume guilt when the crime's really, really bad, but that goes against every good legal standard out there -- and, incidentally, doesn't deter further crime. That is the paradox: Society has a long history of ignoring rape victims, but responding with a process that convicts innocent people just delegitimizes all future convictions and the system as a whole.

Now, wrongful conviction wasn't an issue for Tim, who actually did what he was accused of -- he and the victim were telling the same story. But without a lawyer, who was arguing on his behalf when it came to punishment? Someone in the administration was, hopefully. Tim sure wasn't. All he could do was wait.

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Scott Barbour/Getty Images News/Getty Images

During the investigation, Tim and Vicky described everything that happened that night leading up to the incident. Their stories matched up. They'd each had four or five drinks over the course of the evening, plus wine at her place, yet both claimed alcohol wasn't a factor. They'd talked about crushes. They played games at an arcade bar, and he at one point said, "If I knew you better, I'd slap you on the ass." She said, "Try it," so he did, and they laughed. They ducked into a sex shop on the way to her place. They held hands for a while. At her apartment, she played the piano and sang a sad love song. Her head lay on his chest while they watched TV.

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